Bupropion and Metabolite, Serum/Plasma [8592]

Message

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

BUPROP

Alias/See Also

8592

CPT Codes
80338 (HCPCS: G0480)

Includes

Bupropion and Hydroxybupropion

Preferred Specimen

1 mL frozen serum collected in a red-top tube (no gel)

Minimum Volume

0.4 mL

Other Acceptable Specimens

Frozen plasma collected in: EDTA (lavender-top) tube

Instructions

Collect as trough prior to next dose. Collect serum and remove from cells

Transport Container

Plastic screw-cap vial

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature • Received refrigerated • Gel barrier/Serum Separator Tube (SST®)

Methodology
Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Tues, Thurs, Sat; Report available: Next day

Reference Range

Bupropion	50-100 ng/mL
Hydroxybupropion	600-2000 ng/mL

Clinical Significance

Bupropion is an antidepressant for treating mental depression. Monitoring its level is important to optimize therapy, to avoid toxicity and to assure compliance.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Last Updated: November 24, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.