ALPHA 1 ANTITRYPSIN

Test Code

A1AT

Alias/See Also

ALPHA 1-PROTEASE INHIBITOR

CPT Codes
82103

Preferred Specimen

1mL serum

Minimum Volume

0.5 mL serum

Instructions

Barrier tubes (serum separator tubes) are preferred. If non-barrier tubes are utilized, the serum must be removed immediately after centrifuging and placed in a screw-cap transfer tube.

Collection notes: Avoid hemolysis. Invert tubes at least 8 times. Allow to clot in an upright position for 30 minutes. Within 2 hours, centrifuge tubes 10 minutes. Keep tightly stoppered.

Do NOT re-centrifuge tubes. Do NOT freeze the primary collection tube.

Transport Container

Original tube preferred, may be sent in a screw-top transfer tube.

Transport Temperature

Room temperature

Specimen Stability

Room Temperature: 24 hours
Refrigerated: 7 days
Frozen: at least 7 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis, Lipemia, incorrect specimen type, insufficient sample volume, improper storage conditions, contaminated sample.

Methodology
Immunoturbidimetric Assay

Setup Schedule

Monday and Thursday
BS

Report Available

1-5 days

Reference Range

Normal adult serum: 90 – 200 mg/dL

Clinical Significance

Alpha-1-Antitrypsin level may be increased in normal pregnancy and in several diseases including chronic pulmonary disease; hereditary angioedema; renal, gastric, liver and pancreatic diseases; diabetes; carcinomas and rheumatoid diseases. Alpha-1-Antitrypsin may be decreased in emphysema, hepatic cirrhosis, respiratory distress syndrome of the newborn, nephrosis, malnutrition and cachexia.

Performing Laboratory
CompuNet Clinical Laboratories, LLC
Serology Department
2308 Sandridge Drive
Moraine, Ohio 45439

Last Updated: February 14, 2024

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.