Thipurine Methyltransferase (TPMT) and Nudix Hydrolase (NUDT15) Genotyping, Varies

Message

This test includes genotyping of TPMT and NUDT15, both of which affect metabolism of thiopurine drugs.

Test Code

TPMND

Alias/See Also

6-Mercaptopurine, 6-Thioguanine, TPMT, NUDT15, Thiopurine, thioguanine, mercaptopurine, Chron's Disease, Inflammatory Bowel Disease (IBD), Acute Lymphoblastic Leukemia (ALL), Rheumatoid Arthritis
TPNUQ

CPT Codes
0034u

Physician Attestation of Informed Consent

http://www.mayocliniclabs.com/it-mmfiles/Informed_Consent_for_Genetic_Testing.pdf

Includes

TPMT Genotype, TPMT Phenotype, NUDT15 Genotype, NUDT15 Phenotype, Interpretation, Additional Information, Method, Disclaimer, Reviewed by

Preferred Specimen

1 Lavender tube

Minimum Volume

0.4 mL

Instructions

Invert specimen several time to mix blood. Send whole blood specimen in original tube. Do not aliquot.

Transport Temperature

Room temperature

Specimen Stability

15-30C up to 9 days
2-8C up to 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Methodology
Real-Time PCR with Allelic Discrimination Analysis

FDA Status
LDT

Setup Schedule

Mon - Fri

Report Available

2-4 days

Reference Range

An interpretive report will be provided.

Clinical Significance

Predicting potential for toxicity to thiopurine drugs (6-mercaptopurine, 6-thioguanine, and azathioprine).

Performed By
Alverno Laboratories

Performing Laboratory
Mayo Clinic Laboratories
Test Code: TPNUQ

Last Updated: May 16, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.