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ROS1 Rearrangement by FISH
Test CodeROS1
CPT Codes
88377
Preferred Specimen
Paraffin Block
Minimum Volume
3 Unstained Slides
Transport Temperature
Room temperature
Specimen Stability
- Paraffin blocks are stable up to 10 years at room temperature
- Cut slides are stable up to 60 days at room temperature
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Absence of tumor cells or decalcified specimens will be rejected.
Methodology
Fluorescence In Situ Hybridization (FISH)
Setup Schedule
Monday, 10 PM
Report Available
Report available within 24-48 hours after set up at the performing laboratory.
Reference Range
Mutation not detected
Clinical Significance
Rearrangements of the ROS1 gene have been identified in approximately 1-2% of NSCLS (non-small cell lung cancer) tumors. Crizotinib, a targeted tyrosine kinaze receptor inhibitor, has shown inhibitory growth effects on ROS1 rearranged NSCLC.
Performed By
Alverno Laboratories
Performing Laboratory
Alverno Central Lab
NMB15 (Molecular Biology, FISH)
Last Updated: October 10, 2025

