ROS1 by FISH

Message

Please send two (2) tissue slides or paraffin blocks and one (1) H&E slide with the area of invasive tumor circled.
Send tissue blocks to Molecular in a red pathology interoffice envelope.

Test Code

ROS1

CPT Codes
88377

Transport Temperature

Room temperature

Specimen Stability

Paraffin blocks are stable up to 10 years
Cut slides are stable up to 60 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Absence of tumor cells

Methodology
FISH (Fluorescence In Situ Hybridization)

Setup Schedule

Tuesday; midnight shift

Report Available

Report available within 24 hours of day tested at the performing laboratory.

Reference Range

Mutation not detected

Clinical Significance

Rearrangements of the ROS1 gene have been identified in approximately 1-2% of NSCLS (non-small cell lung cancer) tumors. Crizotinib, a targeted tyrosine kinaze receptor inhibitor, has shown inhibitory growth effects on ROS1 rearranged NSCLC.

Performed By
Alverno Laboratories

Performing Laboratory
Alverno Central Lab
NMB15 (Molecular Biology, FISH)

Last Updated: June 14, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.