THYROGLOBULIN ANTIGEN w/ ANTIBODY SCREEN

Message

Samples that are negative for thyroglobulin antibodies will be referred to Thyroglobulin Ag by Immunoassay.
Samples that are positive for thyroglobulin antibodies will be referred to Thyroglobulin by LC-MS.

Test Code

THGMN

Alias/See Also

THGBL; TPAN; Thyroglobulin

CPT Codes
86800; 84432

Preferred Specimen

1 Gold tube (gel separator)

Minimum Volume

1.5 mL

Other Acceptable Specimens

1 Green tube (Lithium Heparin)

Instructions

Centrifuge for complete separation of serum or plasma and red cells within two (2) hours of collection. If gel separator tube is not used, aliquot (transfer) serum or plasma into a standard transport tube and refrigerate until tested.

Transport Temperature

Refrigerate

Specimen Stability

2-8°C up to 7 days
-20°C or lower samples are stable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

The following conditions will be rejected:

EDTA or K2EDTA plasma
QNS

Methodology
Chemiluminescent Immunoassay or LCMS

Setup Schedule

M, Tu, W, Th, F, Sa, Su

Report Available

Report available within 24 hours of receipt at the performing laboratory.

Reference Range

Thyroglobulin Antibody (0 - 4 IU/mL)
Thyroglobulin Antigen (0.0 - 34.9 ng/mL)

**Thyroglobulin by LCMS Reference Range**
Age	Value (ng/mL)
6 months - 3 years	7.4 - 48.7
4 - 7 years	4.1 - 40.5
8 - 17 years	0.8 - 29.4
18 years and older	1.3 - 31.8

Clinical Significance

Intended to aid in monitoring for the presence of local or metastatic thyroid tissue in patients who have had thyroid gland ablation and who lack serum thyroglobulin antibodies.The presence of serum autoantibodies to thyroglobulin can interfere with immunoassays for thyroglobulin. If the patient is known to have thyroglobulin antibodies please order test code THYLC.

Note: This test has replaced the single-order Thyroglobulin (THGBL) and the Thyroglobulin Panel (TPAN).

Performed By
Alverno Laboratories

Performing Laboratory
Alverno Central Lab
NCHB2 (Chemistry, Beckman DxI)

Last Updated: June 14, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.