LUNG CANCER PANEL

Message

AP Request Form and copy of pathology report must be submitted.

Test Code

LUNGE

CPT Codes
81235; 88381; G0452

Includes

EGFR mutation and Pathologist interpretation

Preferred Specimen

Paraffin block

Minimum Volume

5 Unstained tissue slides

Other Acceptable Specimens

Nine (9) unstained tissue slides, minimum of five (5) dependent on tumor tissue area.

Transport Temperature

Room Temperature

Specimen Stability

Room temperature

Paraffin blocks are stable up to 10 years.
Cut slides are stable for up to 60 days.

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Absence of tumor cells or decalcified specimens will be rejected.

Methodology

EGFR by Real Time Polymerase Chain Reaction (RT-PCR).
If reflexed, ALK & ROS1 by Fluorescence In Situ Hybridization (FISH).

Setup Schedule

EGFR performed Monday-Friday.
Alk & ROS1 set up on Monday at 10:00 PM

Report Available

EGFR result within 1-3 days of receipt at the performing laboratory.
ALK & ROS1 results within 2-7 days of receipt at the performing laboratory.

Reference Range

No mutations detected.

Clinical Significance

Reflexive panel begins with EGFR by PCR for mutation detection. If EGFR demonstrates a wild type status, then reflex testing to ALK and ROS1 by FISH will be performed.

Performed By
Alverno Laboratories

Performing Laboratory
Alverno Central Lab
NMB18 (Molecular Biology, Idylla)

Last Updated: October 8, 2025

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.