THYROPEROXIDASE ANTIBODY

Message

Centrifuge sample within 2 hours of collection. Do not freeze whole blood.

Test Code

TPOAB

Alias/See Also

Thyroid; Microsomal antibody; Antimicrosomal antibody; Antithyroid antibody

CPT Codes
86376

Preferred Specimen

1 Gold tube (gel separator)

Minimum Volume

0.5 mL

Other Acceptable Specimens

1 Lavender tube (EDTA) or
1 Green tube (Lithium Heparin)
Heparin choice is Lithium Heparin only

Instructions

Centrifuge for complete separation of serum and red cells. If plasma is used, sample must be centrifuged and plasma aliquoted/transferred into a transfer tube. Do not send whole blood. Refrigerate until tested.

Transport Temperature

Refrigerate

Specimen Stability

2-8°C up to 7 days
15-30°C up to 8 hours
Frozen samples are stable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolyzed or lipemic samples

Methodology
Chemiluminescent immunoassay

Setup Schedule

M, W, F

Report Available

Report available within 24 hours of testing

Reference Range

<9.0 IU/mL

Clinical Significance

Thyroperoxidase (TPO) is an enzyme that binds Iodine to thyroglobulin to form the building blocks of thyroid hormones T3 and T4. The detection of antibodies against TPO (anti-TPO) can occur in autoimmune thyroid disease. The detection of TPOAb is an aid in the diagnosis of thyroid autoimmune disorders and enables the physician to differentiate thyroid autoimmune disorders from non-autoimmune goiter or hypothyroidism.

Performed By
Alverno Laboratories

Performing Laboratory
Alverno Central Lab
NCHB2 (Chemistry, Beckman DxI)

Last Updated: June 8, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.