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ALK by FISH
MessagePlease send 2 tissue slides or paraffin blocks and 1 H&E slide with the area of invasive tumor circled. Send tissue block to Molecular in a red pathology interoffice envelope.
Test Code
ALKF
CPT Codes
88377
Transport Temperature
Room temperature
Specimen Stability
Room temperature; paraffin blocks are stable up to 10 years and cut slides are stable up to 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Absence of tumor cells
Methodology
Fluorescence In Situ Hybridization (FISH)
Setup Schedule
Tuesday; midnight shift
Report Available
Report available 24-48 hours after set up.
Reference Range
Mutation not detected
Clinical Significance
Patients that exhibit ALK re-arrangements are resistant to EGFR tyrosine kinase inhibitors but may be sensitive to ALK inhibitors. ALK by FISH is indicated for the identification of lung cancer patients who may benefit from ALK inhibitor therapy.
Performed By
Alverno Laboratories
Performing Laboratory
Alverno Central Lab
NMB15 (Molecular Biology, FISH)
Last Updated: June 7, 2023
