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FREE LIGHT CHAIN ASSAY, KAPPA & LAMBDA
MessageThis assay is highly sensitive to increasing concentrations of monoclonal free kappa or free lambda light chains in the serum of patients with evolving or relapsing myelomas.
Test Code
FRLAK
Alias/See Also
Free Light Chain; Serum Free Light Chain
CPT Codes
83521 x2
Includes
Free kappa, free lambda, and free kappa/lambda ratio with interpretation
Preferred Specimen
1 Gold tube (serum serparator)
Minimum Volume
1 mL
Other Acceptable Specimens
1 Red tube
Instructions
Remove serum from cells ASAP after clot forms or within 2 hours of collection.
Transport Temperature
Refrigerated
Specimen Stability
After separation from cells:
- Ambient (15-30C): 2 hours
- Refrigerated (2-8C): 1 week
- Frozen (-20C): 2 weeks
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
The following conditions will result in a rejected specimen:
- Plasma
- Room temperature specimens
Methodology
Quantitative turbidimetry
Setup Schedule
M, T, W, Th, F
Report Available
Within 1-3 days
Reference Range
Kappa: 3.30 - 19.40 mg/L
Lambda: 5.70 - 26.30 mg/L
| Components | Reference Interval |
|---|---|
| Lambda Quantitative Free Light Chains, Serum | 0.57 - 2.63 mg/dL |
| Kappa Quantitative Free Light Chains, Serum | 0.33 - 1.94 mg/dL |
| Kappa/Lambda Free Light Chain Ratio, Serum | 0.26 - 1.65 |
Clinical Significance
Aids in the evaluation and management of multiple myeloma and related plasma cell disorders.
Performed By
Alverno Laboratories
Performing Laboratory
Alverno Central Lab
NCHOP (Chemistry, Optilite)
Last Updated: February 9, 2024
