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BRAF (V600) MUTATION by PCR
MessagePlease send TWO (2) tissue slides or paraffin blocks along with ONE (1) H&E slide with the area of invasion circled. Send tissue block to Molecular in a red Pathology interoffice envelope.
Test Code
CPT Codes
81210; 88381; (G0452)
Other Acceptable Specimens
Transport Temperature
Room temperature
Specimen Stability
Paraffin blocks are stable up to 10 years at room temperature
Cut slides are stable up to 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Absence of tumor cells
Methodology
Real-time PCR performed on deparaffinized and DNA isolated formalin-fixed paraffin embedded tumor tissue sections
Setup Schedule
Batched once per week
Report Available
Reference Range
Mutation not detected
Clinical Significance
BRAF is a human gene that makes a protein called B-Raf. The BRAF gene belongs to a class of genes known as oncogenes. When mutated, oncogenes have the potential to cause normal cells to become cancerous. BRAF by PCR is indicated for identifying melanoma cancers that may respond to treatment with Vemurafenib.
Performed By
Alverno Laboratories
Performing Laboratory
Alverno Central Lab
NMB14 (Molecular Biology, Oncology)
Last Updated: June 6, 2023
