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CHRONIC LYMPHOCYTIC LEUKEMIA / SMALL LYMPHOCYTIC LYMPHOMA PANEL by FISH

Message

Must include Hematopathology Patient Information Sheet with order.  Form is linked in the Additional Information below, in the Resources section, on our website, or by calling Client Services at 219-989-3700.




Test Code
CLLFH


Alias/See Also
CLL


CPT Codes
88377 x2

Includes
Includes Pathologist Interpretation, ATM deletion, TP53 deletion, D135319 deletion, Trisomy 12


Preferred Specimen
Bone marrow or whole blood: 1 Green tube (Sodium Heparin)
Note: Heparin choice is Sodium - do not use Lithium heparin

Lymph node or biopsy: RPMI


Minimum Volume
  • Bone marrow 1 mL
  • Whole blood 1 mL
  • Tissue or lymph node 5x5 mm


Other Acceptable Specimens
None


Instructions
Must include Hematopathology Patient Information Sheet with order.  Form is linked in the Additional Information below, in the Resources section, on our website, or by calling Client Services at 219-989-3700.


Transport Temperature
Whole blood or bone marrow:  Room temperature.  Refrigerated samples will be accepted, but not preferred.
Lymph node or tissue:  Refrigerate in RPMI


Specimen Stability
  • Whole blood or bone marrow: 
    • 15-30°C up to 2 days; Refrigerated samples will be accepted, but not preferred.
  • Lymph node or tissue: 
    • 2-8°C in RPMI up to 2 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted samples will be rejected.
Irretrievable samples will not be rejected.


Methodology
Fluorescence In Situ Hybridization (FISH)

Setup Schedule
Batched


Clinical Significance
This FISH assay uses selected markers for regions of chromosomes 11, 12, 13, and 17 that are useful for prognostic assessment in patients diagnosed by B-cell chronic lymphocytic leukemia.


Performed By
Alverno Laboratories

Performing Laboratory
Alverno Central Lab  
NMB15 (Molecular Biology, FISH)

Additional Information
Hematopathology Patient Information Sheet

Last Updated: April 17, 2024


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.