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Disaccharidases
Test CodeDISTS
Alias/See Also
19701
CPT Codes
82657 (x4)
Includes
Lactase, Maltase, Palatinase, Sucrase
Preferred Specimen
5 mg small bowel biopsy collected in a 2 mL cryovial polypropylene screw-capped tube
Minimum Volume
2 mg
Instructions
Place 5 mg (2 mg minimum) small bowel biopsy on the interior surface of a 2 mL polypropylene screw-capped cryovial or small polypropylene collection tube.
Freeze within 2 hours of collection.
Freeze within 2 hours of collection.
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 31 days
Refrigerated: Unacceptable
Frozen: 31 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Samples frozen later than 2 hours post-collection • Samples received in urine containers • Samples immersed in a colorless fluid (i.e., water, formalin, saline, etc.) • Samples placed on gauze, filter paper or any other type of support media
Methodology
Spectrophotometry (SP)
Setup Schedule
Set up: Sun-Thurs; Report available: 1-3 days after receipt at the performing laboratory. Add three (3) days for transport.
Reference Range
Lactase | 15.0-45.5 uM/min/g prot |
Sucrase | 25.0-69.9 uM/min/g prot |
Maltase | 100.0-224.4 uM/min/g prot |
Palatinase | 5.0-26.3 uM/min/g prot |
Clinical Significance
Lactase, maltase, palatinase and sucrase are mucosal disaccharidases that are present in normal small intestine and fetal colon. A decrease in the enzyme activity of these disaccharidases has been noted in colonic adenomas, adenocarcinomas and malabsorption. Decreased disaccharidase activity is a good indication of mucosal injury with the exception of lactase.
Performing Laboratory
Quest Diagnostics Nichols Institute
27027 Tourney Road
Valencia, CA 91355-5386
Last Updated: June 22, 2023