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Drug Monitoring, Heroin Metabolite, with Confirmation, Urine

Test Code
HERDM


Alias/See Also
39376


CPT Codes
80307

Includes
If you require medMATCH for this order code, you must also order code 39158 - Prescribed Drugs, medMATCH®. If 39158 is ordered, all Drug Monitoring order codes will be treated as medMATCH.

If this test code is not ordered with 39158, all medMATCH result codes will be DNR’d.
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Initial screen of the 6-Acetylmorphine drug class. If screen is positive, a confirmation will be performed at an additional charge (CPT code(s): 80356; G0480).
Confirmation includes the following analytes: 6-Acetylmorphine


Preferred Specimen
20 mL random urine collected in a clinical drug test transport vial


Minimum Volume
7 mL


Other Acceptable Specimens
Random urine collected in a sterile, leak-proof urine container


Transport Temperature
Room temperature


Specimen Stability
Room temperature: 5 days
Refrigerated: 7 days
Frozen: 30 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Preserved samples


Methodology
Screen: Immunoassay (IA) • Confirmation: Mass Spectrometry (MS)

Setup Schedule
Monday-Sunday Evening Report available: 3 Days after receipt at the performing laboratory. Add two (2) days for transport.


Reference Range
6-Acetylmorphine <10 ng/mL
  6-Acetylmorphine <10 ng/mL


Clinical Significance
6-Monoacetylmorphine is the primary metabolite of heroin. The test is a screening assay using a homogeneous enzyme immunoassay method of analysis. Presumptive positive screen results are reflexed to a more specific and sensitive liquid chromatography mass spectroscopy (LC/MS/MS) methodology. Therapeutic urine drug monitoring of 6-Monoacetylmorphine is important for ensuring compliance to treatment strategies. Urine or oral fluid are the specimens of choice for routine monitoring of patients taking prescription drugs. Use of serum/plasma should be limited to anuretic patients, or where a patient's clinical appearance does not coincide with their prescribed medications. No single monitoring approach provides adequate information about the pattern or dose of patient drug use. Safest prescribing habits should include a combination of tools and laboratory test results to correctly detect drug use patterns. Urine drug test results equal to or greater than cutoff are reported as positive and results less than cutoff are reported as negative. Quantitative values cannot be used to assess the drug dose, because the drug is extensively metabolized and excreted in the urine.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153


Last Updated: June 22, 2023


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.