A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Clozapine
Test CodeCLOZA
Alias/See Also
1769
CPT Codes
80159
Includes
Clozapine and Norclozapine
Preferred Specimen
2 mL serum collected in a red-top tube (no gel)
Minimum Volume
1 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, sodium heparin (green-top) tube, or lithium heparin (green-top) tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 24 hours
Refrigerated: 5 days
Frozen: 30 days
Refrigerated: 5 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Gel barrier/Serum separator tube (SST)
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat; Report available: 2 days after receipt at the performing laboratory. Add two (2) days for transport.
Reference Range
Norclozapine | 25-400 mcg/L |
The therapeutic response begins to appear at 100 mcg/L
Refractory schizophrenia appears to require a therapeutic concentration of at least 350 mcg/L (trough, at steady state).
Toxic range: >900 mcg/L
Clinical Significance
Clozapine is an atypical antipsychotic agent. Norclozapine has minimal therapeutic activity.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
Last Updated: June 22, 2023