A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Cortisone, Serum
Test CodeCSONE
Alias/See Also
37098
CPT Codes
82542
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Patient Preparation
Overnight fasting is preferred
Minimum Volume
0.3 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube
Instructions
Specify time of day specimen was collected
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 21 days
Frozen: 1 year
Refrigerated: 21 days
Frozen: 1 year
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Received room temperature • Serum separator tube (SST)
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat; Report available: 3-4 days after receipt at the performing laboratory. Add three (3) days for transport.
Reference Range
AM (mcg/dL) | PM (mcg/dL) | |
Adult Males and Females | 1.2-3.5 | 0.6-2.8 |
AM (mcg/dL) | ||
Full Term Infants, birth** | 2.6-15.6 | |
7 Days** | 0.3-4.5 | |
2 Weeks-3 Months** | 0.9-5.4 | |
4-11 Months | 0.5-4.1 | |
1 Year | 0.5-4.0 | |
2-3 Years | 0.5-3.9 | |
4 Years | 0.5-4.0 | |
5 Years | 0.5-4.1 | |
6 Years | 0.6-4.3 | |
7 Years | 0.7-4.5 | |
8 Years | 0.8-4.7 | |
9 Years | 0.9-4.9 | |
10 Years | 0.9-5.1 | |
11-12 Years | 1.0-5.2 | |
13-17 Years | 1.0-5.3 |
**Pediatric data from Sippell WG et al., Pediat Res (1980) 14:39-46.
Clinical Significance
Measurement of both Free Cortisol and Cortisone are useful in diagnosing patients with low-renin hypertension caused by apparent mineralocorticoid excess. This may be due to either an inherited defect in 11HSDB2 enzyme or an acquired inhibitor of the enzyme by such compounds as glycyrrhizic acid, a component of natural licorice.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |
Last Updated: May 4, 2023