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NT-proBNP
Test CodeNTBNP
Alias/See Also
PBNP; proBNP; proBrain
CPT Codes
83880
Includes
Quantitative measurement of NT-proBNP and interpretation
Preferred Specimen
0.5 mL plasma collected in an EDTA (lavender-top) tube
Minimum Volume
0.3 mL
Instructions
Collect blood in an EDTA (lavender-top) tube. Separate plasma as soon after collection as possible.
Transport Container
Transport tube
Transport Temperature
Refrigerated
Specimen Stability
Room temperature: 24 hours
Refrigerated: 3 days
Frozen: 30 days
Refrigerated: 3 days
Frozen: 30 days
Methodology
Chemiluminescent immunoassay
FDA Status
Approved
Setup Schedule
M, T, W, Th, F, Sa, Su
Report Available
Within 24 hours of receipt at the performing laboratory. Stat testing is available.
Reference Range
< 50 years: ≤ 162 pg/mL
50 - 75 years: ≤ 311 pg/mL
> 75 years: ≤ 457 pg/mL
An age-independent cutoff of 300 pg/mL can be used to identify ED patients in whom heart failure is unlikely and who need further investigations for non-cardiac causes of symptoms (e.g. dyspnea). As renal dysfunction increases, the concentration of NT-proBNP increases and the relationship between the two should be considered during interpretation.
50 - 75 years: ≤ 311 pg/mL
> 75 years: ≤ 457 pg/mL
An age-independent cutoff of 300 pg/mL can be used to identify ED patients in whom heart failure is unlikely and who need further investigations for non-cardiac causes of symptoms (e.g. dyspnea). As renal dysfunction increases, the concentration of NT-proBNP increases and the relationship between the two should be considered during interpretation.
Clinical Significance
Performed By
Alverno Laboratories
Performing Laboratory
Alverno Laboratories
Last Updated: December 16, 2025
