21-Hydroxylase Antibody
Quest #39226

Message

This is the recommended replacement for Adrenal Antibody Screen w/ Reflex to Titer (Quest #8292), which was discontinued 11/24/2025. It should be ordered as an Uncoded, Miscellaneous test (UNCMS).

Test Code

ADRAB (UNCMS)

Alias/See Also

Addison's disease
Adrenal antibody

CPT Codes
83516

Preferred Specimen

0.5 mL serum

Minimum Volume

0.3 mL

Instructions

Transfer serum to a plastic transport vial and ship refrigerated.

Transport Temperature

Refrigerated

Specimen Stability

Room temperature: 5 days
Refrigerated: 14 days
Frozen: 60 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis
Gross icterus

Methodology
Enzyme Linked Immunosorbent Assay (ELISA)

Setup Schedule

Wed

Report Available

5-12 days. Please allow three (3) additional days for transport.

Reference Range

Negative

Clinical Significance

21-Hydroxylase Antibody is present in patients with autoimmune destruction of the adrenal glands, leading to Addison's disease. Antibody is also seen in autoimmune polyglandular syndrome.

Performed By
Alverno Laboratories

Performing Laboratory
Quest Diagnostics - San Juan Capistrano, CA

Last Updated: November 25, 2025

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.

21-Hydroxylase Antibody Quest #39226

21-Hydroxylase Antibody
Quest #39226