RBC Band 3 Protein Reduction in Hereditary Spherocytosis : 1004742

Specimens must be analyzed within 7 days of collection. 

RBCB3 or 1004742

Hereditary Spherocytosis; EMA; BAND 3;  Osmotic Fragility

Lavender (EDTA) or green (sodium or lithium heparin). Include a Wright stained slide.

Transport 4 mL whole blood in the original container. (Min: 0.5 mL) 

Refrigerated.

Ambient: 3 days; Refrigerated: 7 days; Frozen: Unacceptable

Clotted or hemolyzed specimens. Specimens older than 7 days.

Sunday - Saturday

1-3 days  (From receipt at performing laboratory)

This test by flow cytometry has been reported to have a sensitivity of 93 percent for diagnosis of Hereditary Spherocytosis (HS). Congenital Dyserythropoietic Anemia Type II, Southeast Asian Ovalocytosis and Hereditary Pyropoikilocytosis are rare disorders that may have a positive result in this test. 

This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Normal

Use to confirm diagnosis of hereditary spherocytosis when hemolytic anemia and spherocytes are present.