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IgG Synthesis Rate/Index, CSF : 1000191
Test CodeCFINSR or 1000191
CPT Codes
82040, 82042, 82784x2
Includes
Albumin (CSF and Serum); IgG (CSF and Serum); IgG Index, CSF; Synthesis Rate IgG, CSF
Instructions
Both CSF & serum are required specimens. It is preferred that the collection date and time be the same for both; however, it is acceptable for them to be drawn within 48 hours of each other. If no serum is supplied, the client will be contacted to confirm the order.
CSF collection tube #4 is preferred. Submitting 4th lumbar puncture collection tube minimizes blood contamination.
Transport temperature: Refrigerate CSF specimens at 2-8°C in sterile, plastic CSF vial(s) and send refrigerated (cold packs) to the laboratory OR freeze CSF specimens at -20°C and send frozen samples to the laboratory on dry ice.
CSF collection tube #4 is preferred. Submitting 4th lumbar puncture collection tube minimizes blood contamination.
Transport temperature: Refrigerate CSF specimens at 2-8°C in sterile, plastic CSF vial(s) and send refrigerated (cold packs) to the laboratory OR freeze CSF specimens at -20°C and send frozen samples to the laboratory on dry ice.
Transport Container
Specimen
2 mL CSF in a sterile screw cap container and 1 mL serum
Minimum Volume
1 mL CSF and 0.5 mL serum
2 mL CSF in a sterile screw cap container and 1 mL serum
Minimum Volume
1 mL CSF and 0.5 mL serum
Transport Temperature
Refrigerated.
Specimen Stability
Room temperature: 8 hours; Refrigerated: 7 days; Frozen: 90 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis; Received room temperature; Xanthochromia; RBCs; Hemolysis in CSF
Methodology
Nephelometry
Setup Schedule
Monday -Saturday
Report Available
2-5 days (From receipt at performing laboratory)
Reference Range
Synthesis Rate IgG, CSF: -0.9 to +3.3 mg/24 h
IgG Index, CSF: <0.70
IgG, Serum:
Age mg/dL
Cord blood 600-1600
1-28 days 250-600
1-3 months 200-600
4-6 months 160-590
7-11 months 160-800
1 year 280-1040
2 years 330-1120
3-5 years 390-1360
6-8 years 440-1470
9-11 years 480-1530
12-16 years 500-1590
17-60 years 600-1640
61 years or older 600-1540
IgG, CSF: 0.8 – 7.7 mg/dL
Albumin, Serum: 3.6-5.1 g/dL
Albumin, CSF (adults): 8.0 – 42.0 mg/dL
Clinical Significance
The IgG Synthesis Rate/Index is useful in diagnosing and monitoring patients with multiple sclerosis and other inflammatory diseases involving the brain and meninges.
Performing Laboratory
Quest Diagnostics
