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Valproic Acid : 916
Test CodeVALPAU or 916
Alias/See Also
Depakote®,DipropylaceticAcid,Depakene®,Divalproex
CPT Codes
80164
Instructions
Collect as a trough just prior to next dose.
Transport Container
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Alternative Specimens
Plasma collected in: EDTA (lavender-top), sodium heparin (green-top), lithium heparin (green-top), sodium fluoride or potassium oxalate (gray-top), or 3.2% sodium citrate (light blue-top) tube
Minimum Volume
0.2 mL
1 mL serum collected in a red-top tube (no gel)
Alternative Specimens
Plasma collected in: EDTA (lavender-top), sodium heparin (green-top), lithium heparin (green-top), sodium fluoride or potassium oxalate (gray-top), or 3.2% sodium citrate (light blue-top) tube
Minimum Volume
0.2 mL
Transport Temperature
Room temperature.
Specimen Stability
Room temperature: 5 days; Refrigerated: 7 days; Frozen: 30 days
Methodology
Immunoassay
Setup Schedule
Sunday - Saturday
Report Available
1 day
Reference Range
50.0-100.0 mg/L
Clinical Significance
Valproic acid is used as an anticonvulsant to treat certain types of seizures, to prevent migraine headaches and to treat various psychiatric illnesses such as bipolar disorder and aggression. Drugs that compete for protein-binding sites with valproic acid can increase the concentration of valproic acid. Therapeutic drug monitoring is useful to optimize dose. Measurement of the free concentration is useful if toxicity is suspected.
Performing Laboratory
med fusion
