| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Iron, TIBC and Ferritin Panel : 5616
Test CodeFEPANC or 5616
CPT Codes
83540, 83550, 82728
Includes
Total Iron, Iron Binding Capacity, % Saturation (calculated), Ferritin
Instructions
Samples should be taken in the morning from patients in a fasting state, since iron values decrease by 30% during the course of the day and there can be significant interference from lipemia.
Transport Container
Preferred Specimen
2 mL serum
Minimum Volume
1 mL
2 mL serum
Minimum Volume
1 mL
Transport Temperature
Room temperature.
Specimen Stability
Room temperature: 6 days; Refrigerated: 7 days; Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis, Plasma
Methodology
Immunoassay and Spectrophotometry
Setup Schedule
Sunday - Saturday
Report Available
1 day
Reference Range
Iron, Total
Age Male Female
(mcg/dL)
<1 Month 32-112 29-127
1-11 Months 27-109 25-126
1-3 Years 29-91 25-101
4-19 Years 27-164 27-164
20-29 Years 50-195 40-190
30-49 Years 50-180 40-190
≥50 Years 50-180 45-160
Iron Binding Capacity
Age Male Female
mcg/dL (calc)
<1 Month 94-232 94-236
1-5 Months 116-322 89-311
6-11 Months 176-384 138-365
1-19 Years 271-448 271-448
≥20 Years 250-425 250-450
% Saturation
Age Male Female
% (calc)
<1 Year 10-48 12-45
1-12 Years 12-48 13-45
13-19 Years 16-48 15-45
≥20 Years 20-48 16-45
Ferritin
Pediatric
<4 Days Not established
4-14 Days 100-717 ng/mL
15 Days-5 Months 14-647 ng/mL
6-11 Months 8-182 ng/mL
Male
1-4 Years 5-100 ng/mL
5-13 Years 14-79 ng/mL
14-15 Years 13-83 ng/mL
16-18 Years 11-172 ng/mL
19-59 Years 38-380 ng/mL
>59 Years 24-380 ng/mL
Female
1-4 Years 5-100 ng/mL
5-13 Years 14-79 ng/mL
14-18 Years 6-67 ng/mL
19-40 Years 16-154 ng/mL
41-60 Years 16-232 ng/mL
>60 Years 16-288 ng/mL
Clinical Significance
This serum iron study panel may help diagnose iron deficiency or overload. Because ferritin level can be affected by clinical conditions other than iron disorders, the measurement of transferrin saturation—calculated from serum iron level and total iron binding capacity (TIBC)— in the same serum specimen may facilitate the diagnosis of iron deficiency or overload.
Serum ferritin level generally reflects body iron storage and can be used in the diagnosis of iron deficiency and overload. Transferrin saturation is the percentage of iron bound to transferrin. In patients with anemia, ferritin levels are most frequently used to determine whether iron deficiency is the cause. However, as an acute phase protein, ferritin levels can be increased independently of iron status in inflammatory conditions, kidney disease, liver disease, and malignancy. In these clinical scenarios, the combination of ferritin level with other tests, such as transferrin saturation, may aid in the evaluation of iron deficiency.
In patients with suspected hemochromatosis, transferrin saturation and serum ferritin may be included in the initial evaluation of iron overload. The combination of a transferrin saturation under 45% and a normal serum ferritin level may help exclude iron overload. A transferrin saturation equal or over 45% alone or with an elevated ferritin level may suggest further testing. Serum ferritin level is also a predictor of advanced fibrosis.
Note that reference intervals of serum iron, TIBC, transferrin saturation, and ferritin depend upon age and sex.
The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.
Serum ferritin level generally reflects body iron storage and can be used in the diagnosis of iron deficiency and overload. Transferrin saturation is the percentage of iron bound to transferrin. In patients with anemia, ferritin levels are most frequently used to determine whether iron deficiency is the cause. However, as an acute phase protein, ferritin levels can be increased independently of iron status in inflammatory conditions, kidney disease, liver disease, and malignancy. In these clinical scenarios, the combination of ferritin level with other tests, such as transferrin saturation, may aid in the evaluation of iron deficiency.
In patients with suspected hemochromatosis, transferrin saturation and serum ferritin may be included in the initial evaluation of iron overload. The combination of a transferrin saturation under 45% and a normal serum ferritin level may help exclude iron overload. A transferrin saturation equal or over 45% alone or with an elevated ferritin level may suggest further testing. Serum ferritin level is also a predictor of advanced fibrosis.
Note that reference intervals of serum iron, TIBC, transferrin saturation, and ferritin depend upon age and sex.
The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.
Performing Laboratory
med fusion
