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Gliadin (Deamidated) Antibody (IgG, IgA) : 8889
Test CodeGLDNGA or 8889
Alias/See Also
ANTI-GLIADIN AB (IGG,IGA), ANTIGLIADIN AB (IGG,IGA), DGP (IGG,IGA), GLIADIN (IGG,IGA), DEAMIDATED GLIADIN (IGG,IGA)
CPT Codes
86258x2
Includes
Panel includes: IgG and IgA antibodies.
Transport Container
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
1 mL serum
Minimum Volume
0.5 mL
Transport Temperature
Room temperature.
Specimen Stability
Room temperature: 7 days; Refrigerated: 14 days; Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, grossly lipemic
Methodology
Multiplex flow Immunoassay
Setup Schedule
Monday & Wednesday & Friday
Report Available
2-4 days
Reference Range
Gliadin Antibody (IgG)
<15.0 U/mL Antibody not detected
≥15.0 U/mL Antibody detected
Gliadin Antibody (IgA)
<15.0 U/mL Antibody not detected
≥15.0 U/mL Antibody detected
<15.0 U/mL Antibody not detected
≥15.0 U/mL Antibody detected
Gliadin Antibody (IgA)
<15.0 U/mL Antibody not detected
≥15.0 U/mL Antibody detected
Clinical Significance
Detection of antibodies to gliadin, one of the major protein components of gluten, is a sensitive assay useful in diagnosing celiac disease. However, gliadin antibodies may be found in individuals without celiac disease; thus gliadin antibody assays are less specific than assays measuring antibodies to endomysium and transglutaminase. Recent work has revealed that gliadin-reactive antibodies from celiac patients bind to a very limited number of specific epitopes on the gliadin molecule. Further, deamidation of gliadin results in enhanced binding of gliadin antibodies. Based on this information, assays using deamidated gliadin peptides bearing the celiac-specific epitopes have much higher diagnostic accuracy for celiac disease when compared to standard gliadin antibody assays.
Performing Laboratory
med fusion