Phosphatidylserine/Prothrombin (PS/PT) Antibody (IgM) : 11446

Test Code

PSPTM or 11446

Alias/See Also

aPS/PSPT IgM

CPT Codes
83516

Transport Container

Preferred Specimen
0.5 mL Citrated plasma collected from a 3.2% sodium citrate (light blue top) tube

Alternate Specimen
Serum

Transport Temperature

Room temperature.

Specimen Stability

Room temperature: 7 days: Refrigerated: 30 days; Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis, gross lipemia

Methodology
Immunoassay

Setup Schedule

Monday & Wednesday & Friday

Report Available

1-4 days

Reference Range

0-30 U

Clinical Significance

Antiphospholipid Syndrome (APS) is an acquired autoimmune thrombophilia characterized by thrombosis (venous and/or arterial or microvascular) and/or pregnancy loss or morbidity in association with persistent positivity of a heterogeneous group of autoantibodies known as anti-phospholipid antibodies (APL). The international laboratory consensus criteria for the diagnosis of APS includes a positive lupus anticoagulant and/or moderate to high positivity for IgG/IgM Cardiolipin and Beta-2-Glycoprotein I antibodies. Although not included in the criteria classification for APS diagnosis, antibodies directed against a phosphatidylserine/prothrombin complex (PS/PT) have been reported to have a high association with venous thrombosis and obstetric abnormalities, but not with arterial thrombosis. In addition, a very high degree of concordance between the concentration of aPS/PT and lupus anticoagulant activity has been demonstrated.

Performing Laboratory
med fusion

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.