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Phosphatidylserine/Prothrombin (PS/PT) Antibody (IgG) : 11443
Test CodePSPTG or 11443
Alias/See Also
aPS/PSPT IgG
CPT Codes
83516
Transport Container
Preferred Specimen
0.5 mL Citrated plasma collected from a 3.2% sodium citrate (light blue top) tube
Alternate Specimen
Serum
0.5 mL Citrated plasma collected from a 3.2% sodium citrate (light blue top) tube
Alternate Specimen
Serum
Transport Temperature
Room temperature.
Specimen Stability
Room temperature: 7 days: Refrigerated: 30 days; Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, gross lipemia
Methodology
Immunoassay
Setup Schedule
Monday & Wednesday & Friday
Report Available
1-4 days
Reference Range
0-30 U
Clinical Significance
Antiphospholipid Syndrome (APS) is an acquired autoimmune thrombophilia characterized by thrombosis (venous and/or arterial or microvascular) and/or pregnancy loss or morbidity in association with persistent positivity of a heterogeneous group of autoantibodies known as anti-phospholipid antibodies (APL). The international laboratory consensus criteria for the diagnosis of APS includes a positive lupus anticoagulant and/or moderate to high positivity for IgG/IgM Cardiolipin and Beta-2-Glycoprotein I antibodies. Although not included in the criteria classification for APS diagnosis, antibodies directed against a phosphatidylserine/prothrombin complex (PS/PT) have been reported to have a high association with venous thrombosis and obstetric abnormalities, but not with arterial thrombosis. In addition, a very high degree of concordance between the concentration of aPS/PT and lupus anticoagulant activity has been demonstrated.
Performing Laboratory
med fusion