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Rubella Antibody (IgM) : 4422
Test CodeQRUBM or 4422
CPT Codes
86762
Transport Container
Specimen:
1 mL serum
Minimum Volume 0.6 mL
1 mL serum
Minimum Volume 0.6 mL
Transport Temperature
Room temperature.
Specimen Stability
Room Temperature: 4 days; Refrigerated: 7 days; Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, Grossly lipemic
Methodology
Immunoassay
Setup Schedule
Sunday - Saturday
Report Available
1 day (From receipt at performing laboratory)
Reference Range
AU/mL Interpretation
<20.00 Negative
20.00-24.99 Equivocal
≥25.00 Positive
Clinical Significance
Rubella is an acute exanthematous viral infection of children and adults. Rash, fever and lymphadenopathy characterize the illness. While many infections are subclinical, this virus has the potential to cause fetal infection with resultant birth defects. In the absence of a current or recent infection, a demonstration of specific IgG on a serum sample is evidence of immunity to rubella. A positive rubella IgM result does not necessarily indicate current or recent infection. Without a history of exposure to rubella or symptoms consistent with rubella, the IgM result may be difficult to interpret. Rubella IgM can be false positive due to other causes (e.g., parvovirus, rheumatoid factor, cytomegalovirus). Rubella IgM may also persist for more than 12 months after vaccination or natural infection. For a serologic diagnosis of congenital rubella in the neonatal period, antibody to rubella virus should be measured in both infant and maternal sera. If IgM is detected in a newborn infants serum, it is probable that transplacental rubella infection has occurred.
Performing Laboratory
Quest Diagnostics