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Thyroglobulin, Fine Needle Aspirate : 16559
Test CodeTHYFNX or 16559
Alias/See Also
Tg FNA
CPT Codes
84432
Instructions
Preferred: 1 mL fine needle aspirate (FNA) or thyroid-tissue washings submitted in a sterile transport tube (Min. 0.8 mL).
Alternative Specimens: Non-lymph node, Non-nodal soft tissue, or Cervical node washings.
Alternative Specimens: Non-lymph node, Non-nodal soft tissue, or Cervical node washings.
Transport Container
A 25-gauge needle is inserted obliquely within the transducer plane of view and moved back and forth (passes) through the nodule to compensate for patient movement and needle deflection. There is no suction device; cells move into the needle via capillary action.
After collection of the cytology samples, withdraw between 0.10 and 0.25 mL of saline up through each needle and empty this fluid back through the needle into a tube. This is the needle washing used for analysis. Repeat the passes and saline washings from the same biopsied site and empty contents into the same tube. The washes from all needles are pooled (final volume 1 mL).
Inspect specimen for visible blood or tissue contamination. If bloody, centrifuge specimen and transfer supernatant to a new tube to send to the laboratory. The supernatant, not the cellular materials, is used for analysis. If the specimen is clear, centrifugation is not necessary.
Freeze immediately and transport frozen sample to laboratory directly. Do not send specimens in glass tubes.
After collection of the cytology samples, withdraw between 0.10 and 0.25 mL of saline up through each needle and empty this fluid back through the needle into a tube. This is the needle washing used for analysis. Repeat the passes and saline washings from the same biopsied site and empty contents into the same tube. The washes from all needles are pooled (final volume 1 mL).
Inspect specimen for visible blood or tissue contamination. If bloody, centrifuge specimen and transfer supernatant to a new tube to send to the laboratory. The supernatant, not the cellular materials, is used for analysis. If the specimen is clear, centrifugation is not necessary.
Freeze immediately and transport frozen sample to laboratory directly. Do not send specimens in glass tubes.
Transport Temperature
Frozen. Do not send specimens in glass tubes.
Specimen Stability
Room temperature: 14 days; Refrigerated: 7 days; Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Glass tubes
Methodology
Chemiluminescent Immunoassay
Setup Schedule
Sunday - Saturday
Report Available
1 day
Limitations
This test will be performed using the Beckman Coulter chemiluminescent method. Values obtained from different assay methods cannot be used interchangeably. Thyroglobulin levels, regardless of value, should not be interpreted as absolute evidence of the presence or absence of disease.
Reference Range
Negative: ≤1.0 ng/mL
Indeterminate: 1.1-10.0 ng/mL
Consistent with thyroid tissue or metastatic thyroid cancer: >10.0 ng/mL
Indeterminate: 1.1-10.0 ng/mL
Consistent with thyroid tissue or metastatic thyroid cancer: >10.0 ng/mL
Clinical Significance
Clinically enlarged cervical lymph nodes with a history of thyroid cancer are usually assessed by fine-needle aspiration biopsy (FNAB) followed by a cytology. Thyroglobulin (Tg) is frequently elevated in malignant FNAB needle wash specimens and it's use may possibly augment or replace cytology.
Performing Laboratory
med fusion
