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Thyroid Peroxidase and Thyroglobulin Antibodies : 7260
Test CodeTHYABX or 7260
Alias/See Also
Anti-TPO, Anti-Thyroid Microsomal Antibody,TPO, ATG, TGAb
CPT Codes
86800, 86376
Includes
Panel includes: Thyroid Peroxidase and Thyroglobulin Antibodies
Instructions
Serum separator tube (SST) or a plain red top tube.
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
Transport Container
Centrifuge the serum separator tube and transport; if a plain red top tube, centrifuge and aliquot 1.0 mL serum (Min. 0.6 mL) into a standard transport tube.
Transport Temperature
Room temperature.
Specimen Stability
After separation from cells: Room temperature: 7 days; Refrigerated : 7 days; Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, grossly lipemic
Methodology
Immunoassay
Setup Schedule
Sunday - Saturday
Report Available
1 day
Reference Range
Thyroid Peroxidase Ab <9 IU/mL
Thyroglobulin Ab ≤1 IU/mL
Thyroglobulin Ab ≤1 IU/mL
Clinical Significance
Thyroid Peroxidase Antibodies (Anti-TPO/TPOAb) levels determination is the most sensitive test for detecting autoimmune thyroid disease. The highest TPOAb levels are observed in patients suffering from Hashimoto’s thyroiditis. In this disease, the prevalence of TPOAb is about 90% of cases confirming the autoimmune origin of the disease. These autoantibodies also frequently occur (60-80%) in the course of Graves’ disease.
There is a good association between the presence of autoantibodies against TPO and histological thyroiditis. However, in view of the extensive regenerative capacity of the thyroid under the influence of TSH, chronic thyroid disease may be present for years before the clinical manifestation of hypothyroidism becomes evident, if ever.
The detection of TPOAb is an aid in the diagnosis of thyroid autoimmune disorders and enables the physician to differentiate thyroid autoimmune disorders from non-autoimmune goiter or hypothyroidism.
Thyroglobulin antibodies (TGAb) are often present in patients with autoimmune thyroid disease. Approximately 10% of healthy individuals have TGAb at measurable levels. TGAb can be detected in 30% of patients with Graves’ disease and in 85% of patients with Hashimoto’s thyroiditis. However, elevated levels of autoantibodies to thyroid peroxidase (TPO autoantibody) occur more frequently than high TGAb levels in these diseases. Sensitive TGAb methods are needed to identify patient sera that contains thyroglobulin autoantibodies that may interfere with serum thyroglobulin measurements
.
Measurement of thyroglobulin antibodies and thyroid peroxidase antibodies is useful in the diagnosis and management of a variety of thyroid disorders including autoimmune thyroiditis, Hashimoto's Disease, Graves Disease and certain types of goiter.
There is a good association between the presence of autoantibodies against TPO and histological thyroiditis. However, in view of the extensive regenerative capacity of the thyroid under the influence of TSH, chronic thyroid disease may be present for years before the clinical manifestation of hypothyroidism becomes evident, if ever.
The detection of TPOAb is an aid in the diagnosis of thyroid autoimmune disorders and enables the physician to differentiate thyroid autoimmune disorders from non-autoimmune goiter or hypothyroidism.
Thyroglobulin antibodies (TGAb) are often present in patients with autoimmune thyroid disease. Approximately 10% of healthy individuals have TGAb at measurable levels. TGAb can be detected in 30% of patients with Graves’ disease and in 85% of patients with Hashimoto’s thyroiditis. However, elevated levels of autoantibodies to thyroid peroxidase (TPO autoantibody) occur more frequently than high TGAb levels in these diseases. Sensitive TGAb methods are needed to identify patient sera that contains thyroglobulin autoantibodies that may interfere with serum thyroglobulin measurements
.
Measurement of thyroglobulin antibodies and thyroid peroxidase antibodies is useful in the diagnosis and management of a variety of thyroid disorders including autoimmune thyroiditis, Hashimoto's Disease, Graves Disease and certain types of goiter.
Performing Laboratory
med fusion
