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Thyroglobulin Panel : 30278
MessageThyroglobulin antibodies (TGAb) interfere with Thyroglobulin (TG) assays; therefore, TGAb assay should always be performed in conjunction with a TG assay.
Test Code
THROGX or 30278
Alias/See Also
TG, ATG,TGAb
CPT Codes
84432, 86800
Includes
Panel includes: Thyroglobulin and Thyroglobulin Antibody.
Instructions
Serum separator tube (SST) or a plain red top tube.
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
Transport Container
Centrifuge the serum separator tube and transport; if a plain red top tube, centrifuge and aliquot 2.0 mL serum (Min. 1.0 mL) into a standard transport tube.
Transport Temperature
Room temperature.
Specimen Stability
After separation from cells: Room temperature: 7 days; Refrigerated : 7 days; Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, grossly lipemic
Methodology
Immunoassay
Setup Schedule
Sunday - Saturday
Report Available
1 day
Reference Range
Thyroglobulin
Intact Thyroid: 2.8 – 40.9 ng/mL
Athyrotic: <0.1 ng/mL
Note: Abnormal flagging is based upon the reference interval for patients with intact thyroid.
Thyroglobulin Antibodies
< or = 1 IU/mL
Intact Thyroid: 2.8 – 40.9 ng/mL
Athyrotic: <0.1 ng/mL
Note: Abnormal flagging is based upon the reference interval for patients with intact thyroid.
Thyroglobulin Antibodies
< or = 1 IU/mL
Clinical Significance
Thyroglobulin (TG) is a secretory product only of the thyroid gland. The major clinical use of serum TG measurement is to monitor, but not to diagnose, patients with well-differentiated thyroid cancers. The measurement of thyroglobulin, after thyroidectomy and ablation of the thyroid gland, is useful to determine metastasis. Deficient TG synthesis is observed in infants with goitrous hypo-thyroidism. Most patients with thyroid autoimmune disease have thyroglobulin antibody (TGAb). With immunometric assays (sandwich assays), TGAb interference typically produces inappropriately low TG results, most likely caused by endogenous TG immune complexes that block one or more of the reagent antibodies from binding endogenous TG.
Thyroglobulin antibodies (TGAb) are often present in patients with autoimmune thyroid disease. Approximately 10% of healthy individuals have TGAb at measurable levels. TGAb can be detected in 30% of patients with Graves’ disease and in 85% of patients with Hashimoto’s thyroiditis. However, elevated levels of autoantibodies to thyroid peroxidase (TPO autoantibody) occur more frequently than high TGAb levels in these diseases. Sensitive TGAb methods are needed to identify patient sera that contains thyroglobulin autoantibodies that may interfere with serum thyroglobulin measurements.
Thyroglobulin antibodies (TGAb) are often present in patients with autoimmune thyroid disease. Approximately 10% of healthy individuals have TGAb at measurable levels. TGAb can be detected in 30% of patients with Graves’ disease and in 85% of patients with Hashimoto’s thyroiditis. However, elevated levels of autoantibodies to thyroid peroxidase (TPO autoantibody) occur more frequently than high TGAb levels in these diseases. Sensitive TGAb methods are needed to identify patient sera that contains thyroglobulin autoantibodies that may interfere with serum thyroglobulin measurements.
Performing Laboratory
med fusion
