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Thyroid Peroxidase Antibodies : 5081
Test CodeTPABI or 5081
Alias/See Also
Anti-TPO, Anti-Thyroid Microsomal Antibody,TPO, TPOAb
CPT Codes
86376
Instructions
Serum separator tube (SST) or a plain red top tube.
Transport Container
Centrifuge the serum separator tube and transport; if a plain red top tube, centrifuge and aliquot 1.0 mL serum (Min. 0.5 mL) into a standard transport tube.
Transport Temperature
Room temperature.
Specimen Stability
After separation from cells: Room temperature: 10 days; Refrigerated : 14 days; Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Methodology
Immunoassay
Setup Schedule
Sunday - Saturday
Report Available
1 day
Reference Range
<9 IU/mL
Clinical Significance
Thyroid Peroxidase Antibodies (Anti-TPO/TPOAb) levels determination is the most sensitive test for detecting autoimmune thyroid disease. The highest TPOAb levels are observed in patients suffering from Hashimoto’s thyroiditis. In this disease, the prevalence of TPOAb is about 90% of cases confirming the autoimmune origin of the disease. These autoantibodies also frequently occur (60-80%) in the course of Graves’ disease.
There is a good association between the presence of autoantibodies against TPO and histological thyroiditis. However, in view of the extensive regenerative capacity of the thyroid under the influence of TSH, chronic thyroid disease may be present for years before the clinical manifestation of hypothyroidism becomes evident, if ever.
The detection of TPOAb is an aid in the diagnosis of thyroid autoimmune disorders and enables the physician to differentiate thyroid autoimmune disorders from non-autoimmune goiter or hypothyroidism.
There is a good association between the presence of autoantibodies against TPO and histological thyroiditis. However, in view of the extensive regenerative capacity of the thyroid under the influence of TSH, chronic thyroid disease may be present for years before the clinical manifestation of hypothyroidism becomes evident, if ever.
The detection of TPOAb is an aid in the diagnosis of thyroid autoimmune disorders and enables the physician to differentiate thyroid autoimmune disorders from non-autoimmune goiter or hypothyroidism.
Performing Laboratory
med fusion
