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Insulin : 561
Test CodeINSI or 561
CPT Codes
83525
Instructions
Fasting specimen is required.
Serum separator tube (SST) or a plain red top tube.
Serum separator tube (SST) or a plain red top tube.
Transport Container
Centrifuge the serum separator tube and transport; if a plain red top tube, centrifuge and aliquot serum 1.0 mL (Min. 0.5 mL) into a standard transport tube.
Transport Temperature
Refrigerated.
Specimen Stability
After separation from cells: Room temperature: 8 hours; Refrigerated: 7 days; Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis, Plasma, Grossly lipemic
Methodology
Immunoassay
Setup Schedule
Sunday - Saturday
Report Available
1 day
Reference Range
<18.5 uIU/mL
Risk uIU/mL
Optimal ≤18.4
Moderate N/A
High >18.4
Adult cardiovascular event risk category cut points (optimal, moderate, high) are based on Insulin Reference Interval studies performed at Quest Diagnostics in 2022.
Clinical Significance
The measurement of insulin is used in the following investigations:
Diagnosis of diabetes: Insulin levels under basal conditions or after glucose administration are useful for assessing the ability of the pancreasto secrete insulin. Insulin levels are normally low in patients with insulindependent diabetes mellitus (IDDM) and are normal or elevated in patients with non-insulin dependent diabetes mellitus (NIDDM).
Early detection of diabetes: The insulin response to the administration of glucose may be blunted well before the onset of clinical manifestations.
Follow-up and stabilization of insulin-treated diabetics: Insulin assays can be useful at the onset of insulin therapy to evaluate the duration of actionof various insulin preparations.
Predicting complications of Type II diabetes (NIDDM): The persistent elevation of insulin is a risk factor for the development of coronary disease.
Diagnosis of insulinoma: Pancreatic beta-cell tumors may produce a state of hyperinsulinism leading to hypoglycemia.
Diagnosis of diabetes: Insulin levels under basal conditions or after glucose administration are useful for assessing the ability of the pancreasto secrete insulin. Insulin levels are normally low in patients with insulindependent diabetes mellitus (IDDM) and are normal or elevated in patients with non-insulin dependent diabetes mellitus (NIDDM).
Early detection of diabetes: The insulin response to the administration of glucose may be blunted well before the onset of clinical manifestations.
Follow-up and stabilization of insulin-treated diabetics: Insulin assays can be useful at the onset of insulin therapy to evaluate the duration of actionof various insulin preparations.
Predicting complications of Type II diabetes (NIDDM): The persistent elevation of insulin is a risk factor for the development of coronary disease.
Diagnosis of insulinoma: Pancreatic beta-cell tumors may produce a state of hyperinsulinism leading to hypoglycemia.
Performing Laboratory
med fusion
