PSA, Free and Total : 31348

The specimen should be collected prior to prostatic manipulation, such as digital rectal examination (DRE), prostatic massage, transrectal ultrasound (TRUS) and prostatic biopsy as results may be falsely elevated.

Test Code
PSATFX or 31348

Alias/See Also
Fractionated PSA, Prostate Specific Antigen Free and Total, Free PSA and Total PSA, PSA,  PSA Free

CPT Codes
84153, 84154

Panel includes: Total PSA, Free PSA, and  Percent Free PSA.

Serum separator tube (SST) or plain red top tube.

Transport Container
Centrifuge the serum separator tube or plain red top tube, and aliquot 2.0 mL serum (Min. 0.6 mL) into a standard transport tube and freeze.

Transport Temperature

Specimen Stability
After separation from cells: Room temperature: 72 hours, Refrigerated: 72 hours; Frozen: 5 months


Setup Schedule
Sunday - Saturday

Report Available
1 day

PSA was performed using the Beckman Coulter Immunoassay method. Values obtained from different assay methods cannot be used interchangeably. PSA levels, regardless of value, should not be interpreted as absolute evidence of the presence or absence of disease.

Reference Range
PSA, Total
Male:  ≤4.0 ng/mL
Female:  Not established
PSA, Free: See Laboratory Report
PSA, % Free
Male: >25 % (calc)
Female: Not established

Clinical Significance
In men over 50 years with total PSA between 4.0 and 10.0 ng/mL, the percent (%) free PSA gives an estimate of the probability of cancer. In these circumstances the measurement of the % free PSA may aid in avoiding unnecessary biopsies.
 Elevated levels of Prostate Specific Antigen (PSA) have been associated with benign and malignant prostatic disorders. Studies indicate that in men 50 years or older measurement of PSA is a useful addition to the digital rectal exam in the early detection of prostate cancer.
In addition, PSA decreases to undetectable levels following complete resection of the tumor and may rise again with recurrent disease or persist with residual disease. Thus, PSA levels may be of assistance in the management of prostate cancer patients.

Performing Laboratory
med fusion

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.