Voltage-Gated Calcium Channel (VGCC) Type N Antibody : 93882

Test Code
VGCCAB or 93882

Alias/See Also

CPT Codes

Serum separator tube.

Transport Container
Centrifuge serum separator tube. Transfer 1 mL serum into a standard transport tube (Min: 0.5 mL).

Transport Temperature

Specimen Stability
Room temperature: 48 hours; Refrigerated: 48 hours; Frozen: 60 days

Radioimmunoassay (RIA)

Setup Schedule
Monday & Wednesday

Report Available
7-14 days  (From receipt at performing laboratory)

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range
<54 pmol/L

Clinical Significance
N-type calcium channel antibodies are more highly associated with primary lung cancer than P/Q-type. One or all of the autoantibodies in the myasthenia gravis (MG)/LEMS evaluation can occur with neoplasia without evidence of neurological impairment. One or both calcium channel antibodies (P/Q and N) can occur with paraneoplastic and idiopathic cerebellar ataxia, encephalomyeloneuropathies, and autonomic neuropathy. Classical symptoms of LEMS include proximal muscle weakness, fatigability, dry mouth and impotence. When presentation is further complicated with oculobulbar weakness, these symptoms can easily be misinterpreted as MG. However, because VGCC antibodies are positive in only approximately 5% of MG patients, the measurement of these antibodies is very useful in distinguishing LEMS from MG.

Performing Laboratory
Quest Diagnostics

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.