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Hu, Yo, and Ri Antibodies with Reflex to Titers and Western Blot : 90138
Test CodeNEUABS or 90138
Alias/See Also
Anti-Hu; Anti-Ri; Anti-Yo
CPT Codes
86255x3
Includes
Neuronal Nuclear (Hu) Antibody with Reflex to Titer and Western Blot; Neuronal Nuclear (Yo) Antibody with Reflex to Titer and Western Blot; Neuronal Nuclear (Ri) Antibody with Reflex to Titer and Western Blot
If Hu Antibody Screen, IFA is positive, Hu Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181). (ANNHUB,90138-2)
If Hu Antibody, Western Blot is positive, Hu Antibody, Titer will be performed at an additional charge (CPT code(s): 86256). (ANNHUT, 90138-3)
If Yo Antibody Screen, IFA is positive, Yo Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181). (ANNAYO, 90138-5)
If Yo Antibody, Western Blot is positive, Yo Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).(ANNYOT, 90138-6)
If Ri Antibody Screen, IFA is positive, Ri Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181). (ANNRIB, 90138-8)
If Ri Antibody, Western Blot is positive, Ri Antibody, Titer will be performed at an additional charge (CPT code(s): 86256). (ANNRIT, 90138-9)
If Hu Antibody Screen, IFA is positive, Hu Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181). (ANNHUB,90138-2)
If Hu Antibody, Western Blot is positive, Hu Antibody, Titer will be performed at an additional charge (CPT code(s): 86256). (ANNHUT, 90138-3)
If Yo Antibody Screen, IFA is positive, Yo Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181). (ANNAYO, 90138-5)
If Yo Antibody, Western Blot is positive, Yo Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).(ANNYOT, 90138-6)
If Ri Antibody Screen, IFA is positive, Ri Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181). (ANNRIB, 90138-8)
If Ri Antibody, Western Blot is positive, Ri Antibody, Titer will be performed at an additional charge (CPT code(s): 86256). (ANNRIT, 90138-9)
Instructions
Overnight fasting is preferred.
Serum separator tube.
Serum separator tube.
Transport Container
Centrifuge serum separator tube and transport, 1.5 mL serum (Min: 0.6 mL).
Transport Temperature
Refrigerated.
Specimen Stability
Room temperature: 7 days; Refrigerated: 14 days; Frozen: 21 days
Methodology
Immunofluorescence Assay (IFA); if reflex, Western Blot/Titer
Setup Schedule
Varies by assay
Report Available
Varies (From receipt at performing laboratory)
Limitations
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Reference Range
See Laboratory Report
Clinical Significance
Hu anti-neuronal nuclear antibody (anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Purkinje cell (Yo) antibody is found in patients with paraneoplastic cerebellar degeneration and is associated with breast, ovarian, and other gynecologic cancers. Some patients with ovarian cancer have low titers of Yo antibodies in the absence of cerebellar degeneration. Anti-Hu antibodies are associated with paraneoplastic encephalomyelitis and sensory neuropathy. Anti-Ri antibody can be detected in patients with paraneoplastic opsoclonus/myoclonus syndrome. Neoplasms most often associated with anti-Ri include breast cancer, small cell lung cancer, and gynecological cancers.
Performing Laboratory
Quest Diagnostics
