Acetylcholine Receptor Modulating Antibody : 26474

Test Code
AMODAB or 26474

CPT Codes
83519

Instructions
Serum separator tube.

Transport Container
Centrifuge serum separator tube and transport, 1 mL serum (Min: 0.5 mL).

Transport Temperature
Refrigerated.

Specimen Stability
Room temperature: 14 days; Refrigerated: 14 days; Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, Grossly lipemic, Microbially contaminated

Methodology
Radiobinding Assay (RBA)

Setup Schedule
Sunday & Tuesday & Thursday

Report Available
2-7 days  (From receipt at performing laboratory)

Limitations
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range
<32 % Inhibition

Clinical Significance
Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. AChR modulating antibodies cross-link AChR molecules on cell surface, promoting internalization, and decreasing AChR surface density. The AChR binding and modulating antibody assays have similar sensitivities, but performing them together increases sensitivity of antibody detection by approximately 5%.

Performing Laboratory
Quest Diagnostics



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.