Myasthenia Gravis Panel 3 : 10211

Test Code
ACRABT or 10211

Alias/See Also
Acetylcholine Receptor Binding Antibody, Acetylcholine Receptor Blocking Antibody, Acetylcholine Receptor Modulating Antibody, Striated Muscle Antibody

CPT Codes
83519x3, 86255

Includes
Acetylcholine Receptor Binding Antibody, Acetylcholine Receptor Blocking Antibody, Acetylcholine Receptor Modulating Antibody, Striated Muscle Antibody with Reflex to Titer

If Striated Muscle Antibody Screen is positive, then Striated Muscle Antibody Titer will be performed at an additional charge (CPT code(s): 86256)(STMABB, 266-2)
 

Instructions
Serum separator tube.

Transport Container
Centrifuge serum separator tube and transport, 2 mL serum (Min: 0.8 mL).

Transport Temperature
Refrigerated.

Specimen Stability
Room temperature: 4 days; Refrigerated: 14 days; Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis; Grossly lipemic; Microbially contaminated

Methodology
Radioimmunoassay, Radiobinding Assay, Immunofluorescence Assay

Setup Schedule
Monday & Thursday

Report Available
2-6 days  (From receipt at performing laboratory)

Limitations
Acetylcholine Receptor Modulating Antibody & Striated Muscle Antibody Screen: This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range
Acetylcholine Receptor Binding Antibody:
Negative ≤0.30 nmol/L
Equivocal 0.31-0.49 nmol/L
Positive ≥0.50 nmol/L

Acetylcholine Receptor Blocking Antibody:
<15 % Inhibition

Acetylcholine Receptor Modulating Antibody:
<32 % Inhibition

Striated Muscle Antibody:
Negative

Clinical Significance
Myasthenia Gravis is a neurological disorder characterized by a decrease in acetylcholine receptors. Patients exhibit skeletal muscle weakness and fatigability. Approximately 80% of patients with Myasthenia Gravis, excluding ocular involvement only, have detectable acetylcholine receptor antibody. There is a strong correlation between the presence of striated muscle antibody and the presence of thymoma.

Performing Laboratory
Quest Diagnostics



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.