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Acetylcholine Receptor Blocking Antibody : 34459
Test CodeACHRBL or 34459
CPT Codes
83519
Instructions
Serum separator tube.
Transport Container
Centrifuge serum separator tube and transport 1 mL serum (Min: 0.5 mL).
Transport Temperature
Refrigerated.
Specimen Stability
Room temperature: 14 days; Refrigerated: 14 days; Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, Grossly lipemic, Microbially contaminated
Methodology
Radioimmunoassay (RIA)
Setup Schedule
Sunday & Tuesday & Thursday
Report Available
3-6 days (From receipt at performing laboratory)
Reference Range
<15 % Inhibition
Clinical Significance
Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. AChR blocking autoantibodies prevent inter-action of binding antibodies with the AChR. Fewer than 1% of patients have blocking antibodies without binding antibodies. Blocking antibodies are present in about 50% of patients with MG, but rare in other conditions. Therefore, blocking antibodies have utility in ruling out a possible false positive binding assay and detecting the rare patient without AChR binding antibodies.
Performing Laboratory
Quest Diagnostics