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Acetylcholine Receptor Binding Antibody : 206
Test CodeACHBIN or 206
CPT Codes
83519
Instructions
Serum separator tube.
Transport Container
Centrifuge serum separator tube and transport,1 mL serum (Min: 0.5 mL).
Transport Temperature
Refrigerated.
Specimen Stability
Room temperature:14 days; Refrigerated:14 days; Frozen:30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis; Grossly lipemic; Microbially contaminated
Methodology
Radioimmunoassay (RIA)
Setup Schedule
Tuesday - Saturday
Report Available
1-2 days (From receipt at performing laboratory)
Reference Range
Negative ≤0.30 nmol/L
Equivocal 0.31-0.49 nmol/L
Positive ≥0.50 nmol/L
Equivocal 0.31-0.49 nmol/L
Positive ≥0.50 nmol/L
Clinical Significance
Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. This assay aids in the differential diagnosis of conditions with MG-like muscle weakness and in monitoring therapeutic response. If binding antibodies are negative, assays for modulating and blocking antibodies should be considered.
Performing Laboratory
Quest Diagnostics
