Acetylcholine Receptor Binding Antibody : 206

Test Code
ACHBIN or 206

CPT Codes
83519

Instructions
Serum separator tube.

Transport Container
Centrifuge serum separator tube and transport,1 mL serum (Min: 0.5 mL).

Transport Temperature
Refrigerated.

Specimen Stability
Room temperature:14 days; Refrigerated:14 days; Frozen:30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis; Grossly lipemic; Microbially contaminated

Methodology
Radioimmunoassay (RIA)

Setup Schedule
Tuesday - Saturday

Report Available
1-2 days  (From receipt at performing laboratory)

Reference Range
Negative ≤0.30 nmol/L
Equivocal 0.31-0.49 nmol/L
Positive ≥0.50 nmol/L

Clinical Significance
Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. This assay aids in the differential diagnosis of conditions with MG-like muscle weakness and in monitoring therapeutic response. If binding antibodies are negative, assays for modulating and blocking antibodies should be considered.

Performing Laboratory
Quest Diagnostics



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.