HIV-1 Integrase Genotype : 16868

Please provide most recent viral load and date of viral load.

HIVITG or 16868

Isentress (Raltegravir, MK-0518) Resistance, HIV-1 Integrase Strand Transfer Inhibitor, Raltegravir, Elvitegravir, HIV-1 Integrase Mutations, MK-0518

Lavender (EDTA) tube.  Alternative specimen: CSF.

Freshly drawn specimens (whole blood) may be stored at 2° C to 25° C for up to 24 hours prior to centrifugation. Separate plasma from cells within 24 hours of collection by centrifugation.  Transfer 2 mL (Min: 0.6 mL) plasma to a standard transport tube.

CSF: 2 mL; transport in sterile leak-proof container.

Refrigerated.

After separation from cells: Room temperature: 24 hours; Refrigerated: 6 days; Frozen: 42 days

Serum, Whole blood greater than 24 hours old, Frozen whole blood.

Monday  - Saturday

4-8 days  (From receipt at performing laboratory)

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

See Laboratory Report.

The emergence of integrase drug resistance mutations has been observed in vitro and in patients experiencing virologic failure on raltegravir in clinical trials. Twenty three percent of patients receiving raltegravir in a clinical trial experienced virologic failure at 48 weeks and genotypic analysis detected raltegravir associated resistance mutations in 68% of viroligic failures. This assay amplifies and sequences the HIV-1 integrase gene and reports mutations at positions associated with integrase inhibitor drug resistance.