CBFB/MYH11 inv(16), Quantitative, Real-Time PCR : 14992

Test Code

INV16Q or 14992

CPT Codes
81401

Instructions

Whole blood or bone marrow in lavender (EDTA) or green (no gel) (sodium or lithium heparin) or EDTA royal blue

Transport Container

Transport 5 mL (Min: 2 mL) whole blood or 3 mL (Min: 1 mL) bone marrow.

Transport Temperature

Room temperature.

Specimen Stability

Room temperature: 5 days; Refrigerated: 5 days; Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Clotted blood, Gross hemolysis.

Methodology
Real-Time Reverse Transcriptase Polymerase Chain Reaction (RT-PCR)

Setup Schedule

Tuesday

Report Available

5-13 days (From receipt at performing laboratory)

Limitations

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range

Negative

Clinical Significance

This Real-Time Quantitative (Reverse Transcription Polymerase Chain Reaction) for the amplification of CBFB/MYH11 fusion transcript can be used to detect the chromosome aberration of inv (16) or t (16;16). It can be used to detect Minimal Residual Disease (MRD) and assess the risk for disease relapse in inv (16) or t (16;16) Acute Myeloid Leukemia (AML).

Performing Laboratory
Quest Diagnostics

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.