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XX/XY-Opposite Sex Bone Marrow Transplant by FISH : 1003148
MessagePlease provide most recent Pathology report.
Test Code
MDFCPXXXYFG or 1003148
Alias/See Also
Bone Marrow Transplantation, Opposite Sex; FISH (Fluorescent In Situ Hybridization); FISH, Opposite Sex BM Transplant; Fluorescent In Situ Hybridization for Opposite Sex Bone Marrow Transplant; Opposite Sex Bone Marrow Transplantation; XY CEPs; XY FISH; Transplant FISH
CPT Codes
88271x2, 88275
Instructions
Bone Marrow aspirate in a green top sodium heparin tube (2-3 mL) or Peripheral Blood in a green top sodium heparin tube (2-10 mL). Tissue also accepted.
Transport Container
Blood or Bone Marrow: Do not centrifuge. Paraffin embedded formalin fixed tissue that has been fixed in 10% neutral buffered formalin for at least 6 hours and no longer than 48 hours. Two unstained slides, with tissue of 4 microns in thickness are needed for processing, accompanied by a circled H & E clearly indicating the area to be examined.
Transport Temperature
Blood or Bone Marrow: Ambient temperature within 24 hours. Specimen can be refrigerated if not transported immediately. Do not freeze. Protect from heat with a cold pack. Paraffin embedded tissue block: Ambient or on ice pack in summer. Slides: Ambient.
Specimen Stability
Blood and Bone Marrow: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
Paraffin embedded tissue: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Paraffin embedded tissue: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Methodology
Fluorescence in situ hybridization (FISH)
Setup Schedule
Monday - Friday
Report Available
Up to 7 days
Limitations
Laboratory test results should always be considered in the context of clinical observations. This test was developed and its performance characteristics determined by med fusion. It has not been cleared or approved by the U.S. Food and Drug Administration
(FDA). The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments
of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing.
(FDA). The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments
of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing.
Reference Range
An interpretive report will be provided.
Clinical Significance
The purpose of detecting and quantifying the X and Y chromosomes after a sex-mismatched bone marrow transplant is to determine the engraftment success of the transplant. By determining the chromosomal make of the cells, the donor and recipient cells can be compared as a percentage of the total number of cells counted and therefore a percent of recipient cells present after transplantation. This test can be performed in as little as 5 hours, and therefore can be used as a rapid tool in the assessment of engraftment in transplant patients.
Performing Laboratory
med fusion
