Newborn Aneuploidy Panel by FISH : 1004609

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Please submit completed Postnatal Clinical Information Form.  See link in Additional Infomation.
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Test Code
MDFCPCNAP or 1004609

Alias/See Also
FISH for trisomies; Aneuvysion; +21 FISH; +18 FISH; +13 FISH; sex chromosome FISH on newborns; Ambiguous Genitalia;
Down Syndrome, Rule Out By FISH; Edwards Syndrome, Rule Out By FISH; FISH for 13, 18, 21, X, and Y; FISH for NAD; FISH For Newborn Aneusomy

CPT Codes
88271 x5, 88275 x5

Includes
Panel includes: probes for trisomy 13, trisomy 18, trisomy 21 and X and Y.

Instructions
Peripheral Blood in a green top sodium heparin tube (1-2 mL).

Transport Container
Submit whole blood. Do not centrifuge.

Transport Temperature
Ambient temperature within 24 hours. Do not freeze.

Specimen Stability
Ambient: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable

Methodology
Fluorescence in situ hybridization (FISH)

Setup Schedule
Sunday - Saturday

Report Available
1-2 days

Limitations
Laboratory test results should always be considered in the context of clinical observations. This test was developed and its performance characteristics determined by med fusion. It has not been cleared or approved by the U.S. Food and Drug Administration
(FDA). The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments
of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing.

Reference Range
An interpretive report will be provided.

Clinical Significance
Aneuploidy of chromosomes 13, 18, 21, X and Y are most common numerical chromosomal abnormalities detected in newborns. This is a fluorescence in situ hybridization (FISH) based assay and uses a multicolor probe panel (CEP 18, X, Y-alpha satellite, LSI 13 and 21) to detect aneuploidy for chromosomes (13, 18, 21, X and Y) in metaphase and interphase nuclei from peripheral blood of newborns suspected of having numerical chromosomal abnormalities. The assay results are intended to be used in conjunction with other laboratory and clinical findings to make a clinical diagnosis. This FISH assay will not detect the presence of structural chromosome abnormalities that can also result in congenital defects.

Performing Laboratory
med fusion

Additional Information
Postnatal Clinical Information Form


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.