Porphyrins, Fractionation, Quantitative, Random Urine : 36592

Test Code
UPOFRN or 36592


Alias/See Also
Porphyria


CPT Codes
84120

Includes
Coproporphyrin I, Coproporphyrin III, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Uroporphyrin I, Uroporphyrin III, Total Porphyrins


Instructions
Random urine. Protect from light.


Transport Container
Protect from light. Transfer 2 mL aliquot from well mixed random urine to an amber transport tube (preferred) or protect the container from light with foil or place in an amber bag. (Min: 1.5 mL)


Transport Temperature
Refrigerated.


Specimen Stability
Ambient: Unacceptable; Refrigerated: 7 days; Frozen: 30 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature. Not protected from light. Samples with a pH less than 4.0.


Methodology
High Performance Liquid Chromatography (HPLC)

Setup Schedule
Sunday & Tuesday - Friday


Report Available
5-7 days (From receipt at performing laboratory)


Limitations
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.


Reference Range
Adult Reference Ranges:   
Uroporphyrin I:                   3.6-21.1 mcg/g creatinine
Uroporphyrin III:                less than or equal to 5.6 mcg/g creatinine
Heptacarboxyporphyrin:   less than or equal to 3.4 mcg/g creatinine
Hexacarboxyporphyrin:     less than or equal to 6.3 mcg/g creatinine
Pentacarboxyporphyrin:    less than or equal to 4.1 mcg/g creatinine
Coproporphyrin I:                 6.5-33.2 mcg/g creatinine
Coproporphyrin III:               4.8-88.6 mcg/g creatinine
Total Porphyrins:                   27.0-153.6 mcg/g creatinine


Clinical Significance
Clinical use is to diagnose porphyria cutanea tarda, hereditary coproporphyria, variegate porphyria.


Performing Laboratory
Quest Diagnostics



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.