Porphyrins, Fractionation, Quantitative, Random Urine : 36592

Test Code
UPOFRN or 36592

Alias/See Also

CPT Codes

Panel includes: Coproporphyrin I, Coproporphyrin III, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Uroporphyrin I, Uroporphyrin III, Total Porphyrins

Random urine. Protect from light.

Transport Container
Protect from light. Transfer 2 mL aliquot from well mixed random urine to an amber transport tube (preferred) or protect the container from light with foil or place in an amber bag. (Min: 1.5 mL)

Transport Temperature

Specimen Stability
Ambient: Unacceptable; Refrigerated: 7 days; Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature. Not protected from light. Samples with a pH less than 4.0.

High Performance Liquid Chromatography (HPLC)

Setup Schedule
Sunday & Tuesday - Friday

Report Available
5-7 days (From receipt at performing laboratory)

Reference Range
Effective 9/10/2018
Adult Reference Ranges:   
Uroporphyrin I:                   3.6-21.1 mcg/g creatinine
Uroporphyrin III:                less than or equal to 5.6 mcg/g creatinine
Heptacarboxyporphyrin:   less than or equal to 3.4 mcg/g creatinine
Hexacarboxyporphyrin:     less than or equal to 6.3 mcg/g creatinine
Pentacarboxyporphyrin:    less than or equal to 4.1 mcg/g creatinine
Coproporphyrin I:                 6.5-33.2 mcg/g creatinine
Coproporphyrin III:               4.8-88.6 mcg/g creatinine
Total Porphyrins:                   27.0-153.6 mcg/g creatinine

Clinical Significance
Clinical use is to diagnose porphyria cutanea tarda, hereditary coproporphyria, variegate porphyria.

Performing Laboratory
Quest Diagnostics

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.