Monosomy 7/deletion 7q by FISH : 1001110

MDFCPCMONO7 or 1001110

D7S486; 7q-; cen7

Bone Marrow aspirate in a green top sodium heparin tube (2-3 mL) or Peripheral Blood in a green top sodium heparin tube (2-10 mL).

Blood or Bone Marrow: Do not centrifuge.

Blood or Bone Marrow: Ambient temperature within 24 hours. Specimen can be refrigerated if not transported immediately. Do not freeze. Protect from heat with a cold pack.

Blood and Bone Marrow: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable

Monday - Friday

Up to 7 days

Laboratory test results should always be considered in the context of clinical observations. This test was developed and its performance characteristics determined by med fusion. It has not been cleared or approved by the U.S. Food and Drug Administration
(FDA). The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments
of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing.

An interpretive report will be provided.

Deletions of the long arm of chromosome 7(7q-) are commonly observed in MDS and AML, especially in patients with previous exposure to mutagenic agents or radiation therapy. These deletions have been associated with susceptibility to infections, rapid disease progression, and a poor response to therapy. Additionally, deletions of 7q31 are seen in about 40-45% of splenic marginal zone B-cell lymphomas compared to about 8% of other B-cell lymphoproliferative syndromes. A recent study states that 7q deletions in splenic marginal zone B-cell lymphomas are associated with a more aggressive clinical course.