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Lactate Dehydrogenase Isoenzymes : 4411
MessageLD-1 and LD-2 are elevated in hemolyzed specimens. LD-3, LD-4, and LD-5 are labile at low temperatures, and are erroneously low in specimens that have been refrigerated or frozen.
Test Code
LDHISO or 4411
Alias/See Also
LD Isoenzymes
CPT Codes
83625, 83615
Includes
Panel includes: LD isoenzymes (1-5) and LDH, Total.
Instructions
Serum separator tube.
Transport Container
Do not refrigerate or freeze. Centrifuge serum separator tube within 1 hour of collection and transport, 2 mL (Min: 1 mL).
Transport Temperature
Ambient.
Specimen Stability
After separation of cells: Ambient: 7 days; Refrigerated: Unacceptable; Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen. Hemolysis.
Methodology
Spectrophotometry (SP)/Electrophoresis
Setup Schedule
Monday & Wednesday & Friday
Report Available
2-3 days (From receipt at performing laboratory)
Reference Range
Lactate Dehydrogenase (LD)
Male (U/L) Female (U/L)
<1 Month 125-735 145-765
1-11 Months 170-450 190-420
1-3 Years 155-345 165-395
4-6 Years 155-345 135-345
7-10 Years 140-270 140-270
11-13 Years 110-250 110-250
14-17 Years 110-230 110-230
18-49 Years 100-220 100-200
>49 Years 120-250 120-250
Lactate Dehydrogenase Isoenzymes
LD1 18-32 %
LD2 29-42 %
LD3 14-30 %
LD4 6-13 %
LD5 5-18 %
Clinical Significance
Lactate Dehydrogenase (LD) is an enzyme that is present in many different organs and tissues. LD Isoenzymes (LDI) are useful in distinguishing the different isoenzymes expressed differentially in tissues and organs, e.g., cardiac muscle, skeletal muscle, and liver.
Performing Laboratory
Quest Diagnostics
