Lactate Dehydrogenase Isoenzymes : 4411

LD-1 and LD-2 are elevated in hemolyzed specimens. LD-3, LD-4, and LD-5 are labile at low temperatures, and are erroneously low in specimens that have been refrigerated or frozen.

Test Code
LDHISO or 4411

Alias/See Also
LD Isoenzymes

CPT Codes
83625, 83615

Panel includes: LD isoenzymes (1-5) and LDH, Total.

Serum separator tube.

Transport Container
Do not refrigerate or freeze. Centrifuge serum separator tube within 1 hour of collection and transport, 2 mL (Min: 1 mL).

Transport Temperature

Specimen Stability
After separation of cells: Ambient: 7 days; Refrigerated: Unacceptable; Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen. Hemolysis.

Spectrophotometry (SP)/Electrophoresis

Setup Schedule
Monday & Wednesday & Friday

Report Available
2-3 days (From receipt at performing laboratory)

Reference Range
Lactate Dehydrogenase (LD)

                    Male (U/L)  Female (U/L)

<1 Month     125-735 145-765

1-11 Months 170-450 190-420

1-3 Years  155-345 165-395

4-6 Years     155-345 135-345

7-10 Years 140-270 140-270

11-13 Years 110-250 110-250

14-17 Years 110-230 110-230

18-49 Years 100-220 100-200

>49 Years 120-250       120-250


Lactate Dehydrogenase Isoenzymes

LD1 18-32 %

LD2 29-42 %

LD3 14-30 %

LD4 6-13 %

LD5 5-18 %

Clinical Significance
Lactate Dehydrogenase (LD) is an enzyme that is present in many different organs and tissues. LD Isoenzymes (LDI) are useful in distinguishing the different isoenzymes expressed differentially in tissues and organs, e.g., cardiac muscle, skeletal muscle, and liver.

Performing Laboratory
Quest Diagnostics

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.