| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
C1 Inhibitor, Functional : 297
MessageCRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. Do not submit the sample in a glass tube. Do not thaw.
Test Code
C1INFQ or 297
Alias/See Also
Functional C 1-Inhibitor, C1 Esterase inhibitor
CPT Codes
86161
Instructions
Plain red.
Transport Container
Centrifuge plain red and aliquot 1 mL (Min: 0.2 mL) serum into a standard transport tube. Freeze serum within 1 hour of time drawn.
Transport Temperature
Frozen.
Specimen Stability
Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received thawed, Serum separator Tube, Grossly lipemic.
Methodology
Immunoassay
Setup Schedule
Sunday & Tuesday & Thursday
Report Available
1-4 days (From receipt at performing laboratory)
Limitations
Fifteen percent of patient with the inherited form of the disease will test within range.
Reference Range
| greater than equal to 68 % Normal 41-67 % Equivocal less than or equal to 40 % Abnormal Less than 40% of the reference functional activity indicates a likely diagnosis of hereditary angioedema or acquired C1 inhibitor deficiency. |
Clinical Significance
C1 esterase is decreased in angioedema. The inherited form is usually diagnosed in the first two decades of life. The acquired form affects primarily adults with autoimmune or lymphoproliferative disorders. Approximately 15% of patients with hereditary angioedema have a normal concentration of the protein but it is dysfunctional.
Performing Laboratory
Quest Diagnostics
