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C1 Esterase Inhibitor, Protein : 298
Test CodeC1ESI or 298
Alias/See Also
C1 Esterase Inhibitor Antigen (C1 Esterase Inhibitor)
CPT Codes
86160
Instructions
Serum separator tube.
Transport Container
Centrifuge serum separator tube and transport, 1 mL (Min: 0.5 mL).
Transport Temperature
Refrigerated.
Specimen Stability
After separation from cells: Ambient: 7 days; Refrigerated: 8 days; Frozen: 1 year
Methodology
Nephelometry
Setup Schedule
Monday - Saturday
Report Available
1 day (From receipt at performing laboratory)
Limitations
Fifteen percent of patient with the inherited form of the disease will test within range.
Reference Range
21-39 mg/dL
Clinical Significance
The C1 esterase inhibitor protein is a normal constituent of serum which functions as a serine proteinase inhibitor of the serpin family. The C1 esterase inhibitor inhibits the complement proteases C1r and C1s, as well as the proteases kallikrein, factor XIa, XIIa and plasmin of the blood clotting system. The concentration of C1 esterase inhibitor protein is reduced to 10-30% of normal in patients with angioedema secondary to C1 esterase inhibitor deficiency (85% of patients with Hereditary Angioedema (HAE)); In 15% of patients with HAE, the concentrations of the inhibitor protein is normal but function is markedly reduced.
Performing Laboratory
Quest Diagnostics
