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5-Hydroxyindoleacetic Acid (5-HIAA), 24-Hour Urine with Creatinine : 1015172
Test CodeU5H24Q or 1015172
Alias/See Also
5-Hydroxyindoleacetic Acid , Serotonin Metabolite
CPT Codes
83497, 82570
Instructions
Patient should avoid food high in indoles: avocados, banana, tomato, plum, walnut, pineapple, and eggplant.
Collect 24-hour urine. Keep urine refrigerated during and after collection.
Collect 24-hour urine. Keep urine refrigerated during and after collection.
Transport Container
Transport 10 mL aliquot from a well-mixed 24-hour collection, (Min: 5 mL). Keep refrigerated. Record 24-hour total volume on transport container and test request form.
If transported to the laboratory on the same day of the completion of collection, transport refrigerated.
If transport is delayed beyond 24 hours of completion of collection, see below alternate processing/transportation instructions:
A. After urine collection, add 6N HCl to maintain a pH < or = 3. Transport 10 mL aliquot of pH adjusted ( < or = pH 3) urine, refrigerated.
OR
B. If 6N HCL is not available and urine pH is < or = 6, freeze 10 mL aliquot of urine and transport frozen.
If transported to the laboratory on the same day of the completion of collection, transport refrigerated.
If transport is delayed beyond 24 hours of completion of collection, see below alternate processing/transportation instructions:
A. After urine collection, add 6N HCl to maintain a pH < or = 3. Transport 10 mL aliquot of pH adjusted ( < or = pH 3) urine, refrigerated.
OR
B. If 6N HCL is not available and urine pH is < or = 6, freeze 10 mL aliquot of urine and transport frozen.
Transport Temperature
Refrigerated or Frozen.
Specimen Stability
Keep refrigerated during collection. Transport ASAP.
After preservation with 6 N HCL to pH < or = 3: Ambient: 7 days; Refrigerated: 30 days; Frozen: 30 days Unpreserved Urine with pH < or = 6 : Frozen 30 days
After preservation with 6 N HCL to pH < or = 3: Ambient: 7 days; Refrigerated: 30 days; Frozen: 30 days Unpreserved Urine with pH < or = 6 : Frozen 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Preserved urine received refrigerated with pH > 3; Unpreserved urine received frozen with pH > 6.
Methodology
High Performance Liquid Chromatography, Electrochemical Detection
Setup Schedule
Tuesday & Thursday & Friday
Report Available
3-7 days (From receipt at performing laboratory)
Limitations
.
Reference Range
2-10 yrs: less than or equal to 8.0 mg/24 h
>10 yrs: less than or equal to 6.0 mg/24 h
>10 yrs: less than or equal to 6.0 mg/24 h
Clinical Significance
5-HIAA is the end product of serotonin (5-hydroxytryptophan) and tyrptophan metabolism. Patients with carcinoid tumors of the midgut, e.g., ileum, produce high concentrations of 5-HIAA. Patients with carcinoid tumors of the foregut and hindgut may produce little or no 5-HIAA or do so intermittently.
Performing Laboratory
Quest Diagnostics
