NT-proBNP : 11188

Message
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

Test Code
BNPNTQ or 11188

CPT Codes
83880

Instructions
Lavender (EDTA) tube, serum separator tube, plain red tube, or sodium or lithium heparin green top tube.

Transport Container
Centrifuge collection tube ASAP after collection and separate 1 mL (Min: 0.3 mL) plasma or serum into a standard transport tube.

Transport Temperature
Frozen.

Specimen Stability
Ambient: 72 hours; Refrigerated: 5 days; Frozen: 2 years

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis.

Methodology
Electrochemiluminescence (ECLIA)

Setup Schedule
Monday - Friday

Report Available
3-6 days (From receipt at performing laboratory)

Reference Range
18-49 Years:   
less than 300 pg/mL:                           Normal, heart failure unlikely
greater than or equal to 450 pg/mL:       High probability of heart failure
       
50-75 Years:
less than 300 pg/mL:                            Normal, heart failure unlikely
greater than or equal to 900 pg/mL:        High probability of heart failure

greater than 75 Years:
less than 300 pg/mL:                              Normal, heart failure unlikely
greater than or equal to 1800 pg/mL:        High probability of heart failure 

For patients with coronary heart disease, the the optimal risk category cut points for incident of heart failure or CVD death is <253 pg/mL men and <372 pg/mL Women.   For patients with existing heart failure, the optimal risk category cut point for heart failure progression is <300 pg/mL.
 


Clinical Significance
NT-proBNP assay aids in the diagnosis of individuals suspected of congestive heart failure; is indicated for risk stratification of patients with acute coronary syndrome and congestive heart failure. Also aids in the assessment of increased risk of cardiovascular events and mortality for patients at risk of heart failure who have stable coronary artery disease.

Performing Laboratory
Quest Diagnostics



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.