von Willebrand Factor Collagen Binding Assay : 10924

Test Code
VWFCBQ or 10924

CPT Codes

Light Blue top 3.2% sodium citrate tube.

Transport Container
Centrifuge tube and aliquot 1 mL plasma into a standard transport tube (Min: 0.5 mL).

Transport Temperature

Specimen Stability
Ambient: 24 hours; Refrigerated: 24 hours; Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis; Lipemia; Icteric specimen

Enzyme Linked Immunosorbent Immunoassay (ELISA)

Setup Schedule
Monday & Wednesday

Report Available
2-7 days (From receipt at performing laboratory)

This test was performed using a kit that has not been cleared or approved by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics. This test should not be used for diagnosis without confirmation by other medically established means.

Reference Range
vWf:Collagen Binding: 45-198 % normal
Ratio (CBA/vW Ag): greater than or equal to 0.50 ratio

A CBA:vWF AG ratio of <0.5 suggests a qualitative defect of von Willebrand Factor.

Clinical Significance
The Collagen Binding Activity is a surrogate assay for the measurement of von Willebrand Factor (VWF) mediated Platelet adhesion. Decreased activity (collagen bound to the A3 domain of the VWF protein) relative to the VWF antigen level, is observed with qualitative defects of VWF (type 2 disorders). The CBA assay may assist in the discrimination of type 2 disorders. In addition, there have been reports of isolated defects of CBA as a cause for a variant form of von Willebrand disease.

Performing Laboratory
Quest Diagnostics

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.