Valproic Acid, Total and Free : 1016215

Test Code
VALFRQ or 1016215

Alias/See Also

CPT Codes
80164, 80165

Collect as a trough just before next dose. (Optimum time to collect sample: 1 hour before next dose.)

Plain red top tube or lavender (EDTA) top tube.

Transport Container
Centrifuge tube as soon as possible and aliquot 3 mL serum or plasma into a standard transport tube (Min: 1.5 mL).

Transport Temperature

Specimen Stability
Ambient: 48 hours; Refrigerated: 7 days; Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gel barrier tubes.


Setup Schedule
Monday - Saturday

Report Available
1-3 days (From receipt at performing laboratory)

Reference Range
By report.

Clinical Significance
Valproic acid is used as an anticonvulsant to treat certain types of seizures, to prevent migraine headaches, and to treat various psychiatric illnesses such as bipolar disorder and aggression. Drugs that compete for protein-binding sites with Valproic Acid, can increase the concentration of Valproic Acid. Therapeutic drug monitoring is useful to optimize dose. Measurement of the free concentration is useful if toxicity is suspected.

Performing Laboratory
Quest Diagnostics

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.